Testing the Double Cause Hypothesis for Autoimmune Diseases, Dipalmitoylphosphatidylcholine Should be Measured in Plasma or Blood Vessels of Diabetes Type 1?

Introduction: The lung surfactant dipalmitoylphosphatidylcholine (DPPC) leaks into the blood, settling on luminal aspect of blood vessels to create active hydrophobic spots. Nanobubbles are formed at these spots from dissolved gas. We hypothesized that when a large molecule in comes contact with nanobubble spots, its tertiary structure is disrupted. An exposed epitope may then prompt an autoimmune response. In previous study, plasma DPPC diabetes type 1 was higher 2 samples patients within 1.5 years disease compared 8 others longer time disease. Could represent were formed? Methods: measured 10 controls. Results: diabetic group 1.17 ± 0.27 µg/ml , nonsignificantly than control (1.51 0.42 ). Discussion: Leakage not limiting factor for buildup heart lupus mice contained more mice. Further investigation, should explore content animals. If our hypothesis proved true, it open up considerable therapeutic potential.